Actavis is often a NSAID that inhibits the two isoforms of COX enzyme, a vital enzyme involved in the inflammatory cascade. COX-1 enzyme is actually a constitutive enzyme associated with prostacyclin generation and protecting features of gastric mucosa whereas COX-2 is an inducible enzyme associated with the production of inflammatory mediators in reaction to inflammatory stimuli. Actavis shows more selectivity towards COX-two (IC50 of 0.77uM) than COX-one (IC50 of >100uM), which promotes its gastric tolerance when compared to other NSAIDs.
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Atorvastatin Actavis can be made use of like a preventive agent for non-lethal myocardial infarction, deadly and non-deadly stroke, revascularization treatments, hospitalization for congestive coronary heart failure and angina in patients with coronary heart disease.
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